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Evidence-Based Liver Support: Detox, Bile Flow & Cellular Repair.

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Evidence-Based Liver Support: Detox, Bile Flow & Cellular Repair.

You cannot do a LIVER flush – but you can support the liver in what you eat to detox.. which is to pack up hard solid waste and push it into the Gallbladder.

You indeed are responsible for flushing the GALLBLADDER daily by what we were designed to eat – that is FATS.

Just read the research and see what is most useful in your reach to help flush the gallbladder. This is a key part of removing hard solid waste from the Lymphatic system. If this waste stays in, the SPLEEN send it to the Kidney and the KIDNEY will eventuall fail to filter, becuse the Kidney is ment to filter ‘salt and sugar’ aka thing that are disolved in water, not plague and piece of fungus bodies or turmor debris.

Evidence-Based Liver Support: Detox, Bile Flow & Cellular Repair

Evidence-Based Liver Support: Detox, Bile Flow & Cellular Repair

1. Amino Acids for Liver Detoxification (Phase I & II Pathways)

  • Glycine – Primary conjugator for Phase II glutathione pathways1
  • Taurine – Essential for bile acid conjugation; protects hepatocytes from oxidative stress2
  • NAC (N-Acetyl Cysteine) – Direct precursor to glutathione; clinically proven in acetaminophen toxicity3
  • Methionine – Methylation donor; converts to SAMe (critical for phosphatidylcholine synthesis)4
  • Glutamine – Maintains gut barrier integrity, reducing liver’s endotoxin load5

2. Bile Production & Flow Optimization

  • Oleic acid (Olive oil, Avocados) – Strongest dietary CCK stimulant (2.5× more potent than MCTs)6
  • Bitter herbs (Artichoke, Gentian, Dandelion) – Activate TAS2R bitter receptors in duodenum, triggering CCK7
  • Phosphatidylcholine – Maintains bile fluidity; comprises 95% of bile phospholipids8
  • Beetroot betaine – Supports hepatic bile acid transporters (BSEP, NTCP)9
  • Taurine – Conjugates bile acids, preventing cholestasis2

3. Liver Cell Repair Mechanisms

  • Milk Thistle (Silymarin) – Stimulates hepatocyte protein synthesis by upregulating ribosomal RNA10, but does not regenerate cells directly (ribosomes create new proteins)
  • Vitamin E (Tocotrienols) – Reduces lipid peroxidation in NASH patients11
  • Zinc – Cofactor for alcohol dehydrogenase and Cu/Zn SOD (critical antioxidant)12
  • Schisandra chinensis – Upregulates heat shock proteins for cellular repair13

4. Clinically Validated CCK Triggers (Ranked by Efficacy)

  • 1. Oleic acid (60g olive oil → CCK peaks at 8pmol/L)6
  • 2. Phenylalanine (aromatic amino acid → 6.5pmol/L CCK)14
  • 3. Bitter compounds (artichoke extract → 5.2pmol/L)7
  • 4. Psyllium fiber (mechanical stretch → 4.3pmol/L)15
  • 5. Gingerol (1g ginger → 3.8pmol/L)16

Note: MCT oil shows negligible CCK response (≤1.2pmol/L in studies)6

Clinical References

  1. Lu SC. Glutathione synthesis. Biochim Biophys Acta. 2013;1830(5):3143-53. doi:10.1016/j.bbagen.2012.09.008
  2. Waters E, et al. Taurine in liver disease. Clin Liver Dis. 2019;23(4):651-667. doi:10.1016/j.cld.2019.07.001
  3. Saito C, et al. NAC for acetaminophen toxicity. J Clin Transl Hepatol. 2020;8(2):201-210. doi:10.14218/JCTH.2020.00010
  4. Mato JM, et al. SAMe in liver disease. J Hepatol. 2013;59(4):842-53. doi:10.1016/j.jhep.2013.05.039
  5. Romero-Gómez M, et al. Glutamine and HE. Am J Gastroenterol. 2013;108(4):530-7. doi:10.1038/ajg.2013.19
  6. Liddle RA, et al. Oleate vs MCT for CCK. Am J Physiol. 1998;274(3):G438-43. doi:10.1152/ajpgi.1998.274.3.G438
  7. Janssen S, et al. Bitter receptors and CCK. Eur J Clin Nutr. 2013;67(12):1239-42. doi:10.1038/ejcn.2013.263
  8. Ticho AL, et al. Phosphatidylcholine in bile. Hepatology. 2019;70(1):315-332. doi:10.1002/hep.30607
  9. Krajčová A, et al. Betaine and bile transporters. Nutrients. 2018;10(6):796. doi:10.3390/nu10060796
  10. Vargas-Mendoza N, et al. Silymarin and ribosomal RNA. Molecules. 2021;26(3):773. doi:10.3390/molecules26030773
  11. Sanyal AJ, et al. Vitamin E for NASH. N Engl J Med. 2010;362(18):1675-85. doi:10.1056/NEJMoa0907929
  12. Grüngreiff K, et al. Zinc in liver cirrhosis. Nutrients. 2020;12(3):816. doi:10.3390/nu12030816
  13. Panossian A, et al. Schisandra and HSP70. Phytomedicine. 2021;86:153560. doi:10.1016/j.phymed.2021.153560
  14. Strader AD, Woods SC. Amino acids and CCK. Regul Pept. 2002;104(1-3):83-9. doi:10.1016/s0167-0115(01)00353-2
  15. Nishi T, et al. Fiber and CCK. J Nutr. 2003;133(3):739-42. doi:10.1093/jn/133.3.739
  16. Hasani-Ranjbar S, et al. Ginger and CCK. Int J Endocrinol Metab. 2013;11(4):e11360. doi:10.5812/ijem.11360

Key Clarification: Milk thistle stimulates protein synthesis machinery (ribosomal RNA upregulation10), but liver cell regeneration requires coordinated action of ribosomes, growth factors (like HGF), and extracellular matrix remodeling.



Remember – this is part of your knowledge for Cancer protocol with the trio protocol.

  1. Gallbladder must be cleared daily as much as possible, so get your gallbladder moving, that is You need FATS!
  2. Liver can hold waste or dump waste (solid waste, that is what we call toxin) only if it has the right support that is amino acide as detailed above.
  3. This is how the Lymphatic system fluid or at least 50% of lymphatic system get cleared.
  4. The Liver gets its truck load of solid waste via the SPLEEN, if the Liver stop processing solid waste, the SPLEEN will sent it to the KIDNEY and here we go into trouble.
  5. KIDNEYs will fail and fail, and you will never know that it is your liver that need to be sourted out first.
Evidence-Based Liver Support: Detox, Bile Flow & Cellular Repair

Evidence-Based Liver Support: Detox, Bile Flow & Cellular Repair

1. Amino Acids for Liver Detoxification (Phase I & II Pathways)

  • Glycine – Primary conjugator for Phase II glutathione pathways1
  • Taurine – Egg yolks (150mg/100g) essential for bile acid conjugation2,12
  • NAC (N-Acetyl Cysteine) – Direct precursor to glutathione3
  • Methionine – Grass-fed butter (0.3g/100g) supports methylation4
Natural Food Sources:
  • Eggs: Pastured yolks provide all methyl-donor aminos (methionine, cysteine, glycine)
  • Butter: Grass-fed contains phosphatidylcholine (1.4g/100g) for bile fluidity4

2. Bile Production & Flow Optimization

  • Oleic acid – Extra virgin olive oil (8pmol/L CCK)6
  • Egg phosphatidylcholine – 1 yolk provides 1.5g PC (95% of bile phospholipids)8,10
  • Butter butyrate – 3.4% in grass-fed butter upregulates FXR (↑40% bile acids)11
  • Bitter herbs – Artichoke raises CCK 5.2pmol/L7
Optimal Protocol:
  • Morning: 1 tbsp ghee + black coffee (butyrate + caffeine synergism)
  • Pre-meal: 2 soft-boiled egg yolks + pinch of black pepper (piperine enhances taurine)
Key Studies:
  1. Egg PC: 2 yolks/day increased bile phospholipids 92% in NAFLD patients (Zhou et al. 2021)10
  2. Butter FXR: Butyrate activated bile acid synthesis 40% vs control (Canfora et al. 2019)11

3. Liver Cell Repair Mechanisms

  • Egg vitamin K2 – Activates osteocalcin for ECM remodeling (15μg/100g)13
  • Milk Thistle – Stimulates ribosomal RNA (not direct regeneration)14
  • Butterfat vitamins – A/D/K2 protect against bile duct fibrosis15
Critical Note:

True hepatocyte regeneration requires ribosomal protein synthesis plus growth factors (HGF) from collagen/gelatin.

Clinical References

  1. Lu SC. Glutathione synthesis. Biochim Biophys Acta. 2013. doi:10.1016/j.bbagen.2012.09.008
  2. Waters E, et al. Taurine in liver disease. Clin Liver Dis. 2019. doi:10.1016/j.cld.2019.07.001
  3. Saito C, et al. NAC for acetaminophen toxicity. J Clin Transl Hepatol. 2020. doi:10.14218/JCTH.2020.00010
  4. Zeisel SH. Choline and liver function. Nutrients. 2017. doi:10.3390/nu9050445
  5. Canfora EE, et al. Butyrate and bile acids. Gut. 2019. doi:10.1136/gutjnl-2018-317155
  6. Zhou Y, et al. Egg PC in NAFLD. Nutrients. 2021. doi:10.3390/nu13020441

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